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<http://fhircat.org/cord-19/metadata/55322bfc591eeae6d68a9826baaebf6ec74234ca> fhir_link: <https://fhircat.org/cord-19/fhir/Commercial/55322bfc591eeae6d68a9826baaebf6ec74234ca> ;
    dc:abstract "Impaired innate and adaptive immune responses are evidenced throughout the course of PRRSV infection. We previously reported that interleukin-1 receptor antagonist (IL-1Ra) was involved in PRRSV-induced immunosuppression during an early phase of infection. However, the exact mechanism associated with PRRSV-induced IL-1Ra immunomodulation remains unknown. To explore the immunomodulatory properties of PRRSV-induced IL-1Ra on porcine immune functions, monocyte-derived dendritic cells (MoDC) and leukocytes were cultured with type 2 PRRSV, and the immunological role of IL-1Ra was assessed by addition of anti-porcine IL-1Ra Ab. The results demonstrated that PRRSV-induced IL-1Ra reduced phagocytosis, surface expression of MHC II (SLA-DR) and CD86, as well as downregulation of IFNA and IL1 gene expression in the MoDC culture system. Interestingly, IL-1Ra secreted by the PRRSV-infected MoDC also inhibited T lymphocyte differentiation and proliferation, but not IFN-γ production. Although PRRSV-induced IL-1Ra was not directly linked to IL-10 production, it contributed to the differentiation of regulatory T lymphocytes (Treg) within the culture system. Taken together, our results demonstrated that PRRSV-induced IL-1Ra downregulates innate immune functions, T lymphocyte differentiation and proliferation, and influences collectively with IL-10 in the Treg induction. The immunomodulatory roles of IL-1Ra elucidated in this study increase our understanding of the immunobiology of PRRSV." ;
    dc:creator "['Nedumpun, Teerawut', 'Techakriengkrai, Navapon', 'Thanawongnuwech, Roongroje', 'Suradhat, Sanipa']" ;
    dc:identifier <http://dx.doi.org/10.3389/fimmu.2019.00579>,
        <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443931>,
        <https://www.ncbi.nlm.nih.gov/pubmed/30972072> ;
    dc:issued "2019-01-01"^^xsd:date ;
    dc:license "CC BY" ;
    dc:title "Negative Immunomodulatory Effects of Type 2 Porcine Reproductive and Respiratory Syndrome Virus-Induced Interleukin-1 Receptor Antagonist on Porcine Innate and Adaptive Immune Functions" ;
    sso:has_full_text "True" ;
    sso:journal "Front Immunol" ;
    sso:sha "55322bfc591eeae6d68a9826baaebf6ec74234ca" ;
    sso:source_x "PMC" .