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<http://fhircat.org/cord-19/metadata/723d2ca57cbcc702c68347fb8183376d16d80f1a> fhir_link: <https://fhircat.org/cord-19/fhir/Non-comercial/723d2ca57cbcc702c68347fb8183376d16d80f1a> ;
    dc:abstract "It is well known that the local renin-angiotensin system (RAS) is activated in the diabetic state, which results in an increase in the level of oxidative stress injury to pancreatic β cells. The angiotensin-converting enzyme 2 (ACE2)/angiotensin (1-7) [Ang (1-7)]/Mas axis is a negative regulator of the classical renin-angiotensin system. In order to investigate the antioxidant effect of Ang (1-7) on pancreatic β cells, INS-1 cells were cultured and oxidative stress was induced by treatment with H(2)O(2). Glucose-stimulated insulin secretion (GSIS), the generation of reactive oxygen species (ROS), mitochondrial membrane potential (MMP) and glucose-stimulated calcium (GSCa) responses in β cells were determined following treatment with Ang (1-7). It was observed that H(2)O(2) significantly impaired the insulin secreting function, increased the production of ROS, and also decreased the levels of GSCa and MMP. Pre-treatment with Ang (1-7) alleviated these effects and treatment with A779 [antagonist of Ang (1-7)] prevented the effects of Ang (1-7). Based on these findings, it was concluded that Ang (1-7) can protect pancreatic β cells from oxidative injury and such protection can be blocked by its antagonist A779." ;
    dc:creator "['Zhang, Fen', 'Liu, Chang', 'Wang, Lei', 'Cao, Xi', 'Wang, Ying Ying', 'Yang, Jin Kui']" ;
    dc:identifier <http://dx.doi.org/10.3892/mmr.2016.5514>,
        <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991744>,
        <https://www.ncbi.nlm.nih.gov/pubmed/27430410> ;
    dc:issued "2016-01-01"^^xsd:date ;
    dc:license "CC BY-NC-ND" ;
    dc:title "Antioxidant effect of angiotensin (1-7) in the protection of pancreatic β cell function" ;
    sso:has_full_text "True" ;
    sso:journal "Mol Med Rep" ;
    sso:sha "723d2ca57cbcc702c68347fb8183376d16d80f1a" ;
    sso:source_x "PMC" .