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dc:abstract "ABSTRACT: A series of diethyl 2-(4,5-dimethoxycarbonyl-1H-1,2,3-triazol-1-yl)alkylphosphonates was synthesised from ω-azidoalkylphosphonates and dimethyl acetylenedicarboxylate and was further transformed into the respective diamides, dihydrazides, and 5,6-dihydro-1H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-diones as phosphonate analogues of acyclic nucleosides having nucleobases replaced with substituted 1,2,3-triazoles. All compounds containing P–C–C–triazole or P–C–C–CH(2)–triazole moieties exist in single conformations in which the diethoxyphosphoryl and substituted 1,2,3-triazolyl or substituted (1,2,3-triazolyl)methyl groups are oriented anti. All phosphonates were evaluated in vitro for activity against a variety of DNA and RNA viruses. None of the compounds were endowed with antiviral activity. They were not cytostatic at 100 μM. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s00706-013-1137-x) contains supplementary material, which is available to authorized users." ;
dc:creator "['Bankowska, Emilia', 'Balzarini, Jan', 'Głowacka, Iwona E.', 'Wróblewski, Andrzej E.']" ;
dc:identifier ,
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dc:issued "2014-01-01"^^xsd:date ;
dc:license "NO-CC CODE" ;
dc:title "Design, synthesis, antiviral and cytotoxic evaluation of novel acyclic phosphonate nucleotide analogues with a 5,6-dihydro-1H-[1,2,3]triazolo[4,5-d]pyridazine-4,7-dione system" ;
sso:has_full_text "False" ;
sso:journal "Monatsh Chem" ;
sso:sha "22c981d032c93d30406d585ce81ba5d8dc4fda31" ;
sso:source_x "PMC" .