{
   "source_x": "PMC",
   "title": "Delineating antibody recognition against Zika virus during natural infection",
   "doi": "http://dx.doi.org/10.1172/jci.insight.93042",
   "pmcid": "PMC5470883",
   "abstract": "Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that shares a considerable degree of homology with dengue virus (DENV). Here, we examined longitudinal antibody response against ZIKV during natural infection in 2 convalescent individuals. By decomposing the antibody recognition into DI/DII and DIII of the E glycoprotein, we showed their development in humans followed a spatiotemporal hierarchy. Plasma binding to DI/DII appeared to peak and wane during early infection with extensive cross-reactivity with DI/DII of DENV. Binding to DIII, however, peaked early but persisted months into the infection without detectable cross-reactivity with DIII of DENV. A clear trend of increase in DIII-specific neutralizing activity was observed over the course of infection. mAbs isolated during early infection are largely DI/DII specific, weakly neutralizing, and highly cross-reactive with DENV, while those from later infection are more diverse in recognition, potently neutralizing, and ZIKV specific. The most potent neutralizing mAb targeting the DIII provided 100% protection in mice from lethal ZIKV infection and could therefore serve as a promising candidate for antibody-based therapy and prevention. The dynamic features unveiled here will assist us to better understand the pathogenesis of ZIKV infection and inform rational design of vaccines.",
   "authors": [
      "['Yu, Lei', 'Wang, Ruoke', 'Gao, Fei', 'Li, Min', 'Liu, Jianying', 'Wang, Jian', 'Hong, Wenxin', 'Zhao, Lingzhai', 'Wen, Yingfen', 'Yin, Chibiao', 'Wang, Hua', 'Zhang, Qi', 'Li, Yangyang', 'Zhou, Panpan', 'Zhang, Rudian', 'Liu, Yang', 'Tang, Xiaoping', 'Guan, Yongjun', 'Qin, Cheng-Feng', 'Chen, Ling', 'Shi, Xuanling', 'Jin, Xia', 'Cheng, Gong', 'Zhang, Fuchun', 'Zhang, Linqi']"
   ],
   "id": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5470883"
}