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<http://fhircat.org/cord-19/metadata/fe2000f280297c40bc53ce95d703a9ca6aac19fd> fhir_link: <https://fhircat.org/cord-19/fhir/Commercial/fe2000f280297c40bc53ce95d703a9ca6aac19fd> ;
    dc:abstract "A number of paramyxoviruses are responsible for acute respiratory infections in children, elderly and immuno-compromised individuals, resulting in airway inflammation and exacerbation of chronic diseases like asthma. To understand the molecular pathogenesis of these infections, we searched for cellular targets of the virulence protein C of human parainfluenza virus type 3 (hPIV3-C). We found that hPIV3-C interacts directly through its C-terminal domain with STAT1 and GRB2, whereas C proteins from measles or Nipah viruses failed to do so. Binding to STAT1 explains the previously reported capacity of hPIV3-C to block type I interferon signaling, but the interaction with GRB2 was unexpected. This adaptor protein bridges Epidermal Growth Factor (EGF) receptor to MAPK/ERK pathway, a signaling cascade recently found to be involved in airway inflammatory response. We report that either hPIV3 infection or transient expression of hPIV3-C both increase cellular response to EGF, as assessed by Elk1 transactivation and phosphorylation levels of ERK1/2, 40S ribosomal subunit protein S6 and translation initiation factor 4E (eIF4E). Furthermore, inhibition of MAPK/ERK pathway with U0126 prevented viral protein expression in infected cells. Altogether, our data provide molecular basis to explain the role of hPIV3-C as a virulence factor and determinant of pathogenesis and demonstrate that Paramyxoviridae have evolved a single virulence factor to block type I interferon signaling and to boost simultaneous cellular response to growth factors." ;
    dc:creator "['Caignard, Grégory', 'Komarova, Anastassia V.', 'Bouraï, Mehdi', 'Mourez, Thomas', 'Jacob, Yves', 'Jones, Louis M.', 'Rozenberg, Flore', 'Vabret, Astrid', 'Freymuth, François', 'Tangy, Frédéric', 'Vidalain, Pierre-Olivier']" ;
    dc:identifier <http://dx.doi.org/10.1371/journal.ppat.1000587>,
        <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2736567>,
        <https://www.ncbi.nlm.nih.gov/pubmed/19806178> ;
    dc:issued "2009-01-01"^^xsd:date ;
    dc:license "CC BY" ;
    dc:title "Differential Regulation of Type I Interferon and Epidermal Growth Factor Pathways by a Human Respirovirus Virulence Factor" ;
    sso:has_full_text "True" ;
    sso:journal "PLoS Pathog" ;
    sso:sha "fe2000f280297c40bc53ce95d703a9ca6aac19fd" ;
    sso:source_x "PMC" .