{
   "source_x": "PMC",
   "title": "Long non-coding RNAs and control of gene expression in the immune system",
   "doi": "http://dx.doi.org/10.1016/j.molmed.2014.09.002",
   "pmcid": "PMC4252818",
   "abstract": "All cells of the immune system rely on a highly integrated and dynamic gene expression program that is controlled by both transcriptional and post-transcriptional mechanisms. Recently, non-coding RNAs, including long non-coding RNAs (lncRNA), have emerged as important regulators of gene expression in diverse biological contexts. Long non-coding RNAs control gene expression in the nucleus by modulating transcription or via post-transcriptional mechanisms targeting the splicing, stability or translation of mRNAs. Our knowledge of lncRNA biogenesis, their cell-type specific expressions, and their versatile molecular functions are rapidly progressing in all areas of biology. Here we discuss these exciting new regulators and highlight an emerging paradigm of lncRNA-mediated control of gene expression in the immune system.",
   "authors": [
      "['Atianand, Maninjay K.', 'Fitzgerald, Katherine A.']"
   ],
   "id": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4252818"
}