{
   "source_x": "PMC",
   "title": "Two cis-acting signals control ribosomal frameshift between human T-cell leukemia virus type II gag and pro genes.",
   "pmcid": "PMC238052",
   "abstract": "The open reading frame of the human T-cell leukemia virus type II pro gene is arranged at a -1 position relative to the gag gene. Synthesis of the Gag-Pro fusion polyprotein is facilitated by ribosomal frameshift into the reading frame of the pro gene. Cloning of a synthetic 41-bp oligonucleotide corresponding to the gag-pro junction within a heterologous gene (nef of human immunodeficiency virus type I) and mutation analysis revealed that two cis-acting signals, an adenosine residue stretch and a dyad symmetry sequence, flanking the UAA termination codon, are required for efficient ribosomal frameshifting between gag and pro. The stability of the stem-loop structure is crucial for frameshifting.",
   "authors": [
      "['Falk, H', 'Mador, N', 'Udi, R', 'Panet, A', 'Honigman, A']"
   ],
   "id": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC238052"
}