{
   "sha": "5136621ef7ae0c8d8b2dd396e432bedceb3f0331",
   "source_x": "PMC",
   "title": "Identification and Characterization of a Novel Alpaca Respiratory Coronavirus Most Closely Related to the Human Coronavirus 229E",
   "doi": "http://dx.doi.org/10.3390/v4123689",
   "pmcid": "PMC3528286",
   "pubmed_id": "23235471",
   "license": "CC BY",
   "abstract": "In 2007, a novel coronavirus associated with an acute respiratory disease in alpacas (Alpaca Coronavirus, ACoV) was isolated. Full-length genomic sequencing of the ACoV demonstrated the genome to be consistent with other Alphacoronaviruses. A putative additional open-reading frame was identified between the nucleocapsid gene and 3'UTR. The ACoV was genetically most similar to the common human coronavirus (HCoV) 229E with 92.2% nucleotide identity over the entire genome. A comparison of spike gene sequences from ACoV and from HCoV-229E isolates recovered over a span of five decades showed the ACoV to be most similar to viruses isolated in the 1960\u2019s to early 1980\u2019s. The true origin of the ACoV is unknown, however a common ancestor between the ACoV and HCoV-229E appears to have existed prior to the 1960\u2019s, suggesting virus transmission, either as a zoonosis or anthroponosis, has occurred between alpacas and humans.",
   "publish_time": "2012 Dec 12",
   "authors": [
      "['Crossley, Beate M.', 'Mock, Richard E.', 'Callison, Scott A.', 'Hietala, Sharon K.']"
   ],
   "journal": "Viruses",
   "has_full_text": "True",
   "id": "5136621ef7ae0c8d8b2dd396e432bedceb3f0331",
   "fhir_link": "Commercial/5136621ef7ae0c8d8b2dd396e432bedceb3f0331"
}