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dc:abstract "Tylophorine compounds have been the focus of drug development for decades. Tylophorine derivatives exhibit anti-cancer activities but their cellular targets remain unknown. We used a biotinylated tylophorine derivative to probe for the interacting cellular target(s) of tylophorine. Tylophorine directly binds to caprin-1 and consequently enhances the recruitment of G3BP1, c-Myc mRNA, and cyclin D2 mRNA to form a ribonucleoprotein complex. Subsequently, this tylophorine targeted ribonucleoprotein complex is sequestered to the polysomal fractions and the protein expressions of the associated mRNA-transcripts are repressed. Caprin-1 depleted carcinoma cells become more resistant to tylophorine, associated with decreased formation of the ribonucleoprotein complex targeted by tylophorine. Consequently, tylophorine downregulates c-Myc and cyclins D1/D2, causing hypophosphorylation of Rb and suppression of both processing-body formation and the Warburg effect. Gene expression profiling and gain-of-c-Myc-function experiments also revealed that the downregulated c-Myc contributes to the anti-oncogenic effects of tylophorine compounds. Furthermore, the potent tylophorine derivative dibenzoquinoline-33b elicited a similar effect, as c-Myc protein levels were also decreased in xenograft tumors treated with dibenzoquinoline-33b. Thus, tylophorine compounds exert anti-cancer activity predominantly by targeting and sequestering the caprin-1 protein and c-Myc mRNA associated ribonucleoprotein complex." ;
dc:creator "['Qiu, Ya-Qi', 'Yang, Cheng-Wei', 'Lee, Yue-Zhi', 'Yang, Ruey-Bing', 'Lee, Chih-Hao', 'Hsu, Hsing-Yu', 'Chang, Chien-Chung', 'Lee, Shiow-Ju']" ;
dc:identifier ,
;
dc:issued "2014-01-01"^^xsd:date ;
dc:license "CC BY" ;
dc:title "Targeting a ribonucleoprotein complex containing the caprin-1 protein and the c-Myc mRNA suppresses tumor growth in mice: an identification of a novel oncotarget" ;
sso:has_full_text "True" ;
sso:journal "Oncotarget" ;
sso:sha "9de48553eac5b5676f0e796f544e04634d39aaa4" ;
sso:source_x "PMC" .