{
   "sha": "5ef330551dd1c93b532c49305501f9a5abd3d799",
   "source_x": "PMC",
   "title": "T Cell Response in Patients with Implanted Biological and Mechanical Prosthetic Heart Valves",
   "doi": "http://dx.doi.org/10.1155/2016/1937564",
   "pmcid": "PMC4773556",
   "pubmed_id": "26989331",
   "license": "CC BY",
   "abstract": "The study was aimed at assessing T cell subsets of peripheral blood from recipients of long-term functioning (more than 60 months) biological and mechanical heart valve prostheses. The absolute and relative number of CD4 and CD8 T cell subsets was analyzed: na\u00efve (N, CD45RA(+)CD62L(+)), central memory (CM, CD45RA(\u2212)CD62L(+)), effector memory (EM, CD45RA(\u2212)CD62L(\u2212)), and terminally differentiated CD45RA-positive effector memory (TEMRA, CD45RA(+)CD62L(\u2212)) in 25 persons with biological and 7 with mechanical prosthesis compared with 48 apparently healthy volunteers. The relative and absolute number of central memory and na\u00efve CD3(+)CD8(+) in patients with biological prosthesis was decreased (p < 0.001). Meanwhile the number of CD45RA(+)CD62L(\u2212)CD3(+)CD8(+) and CD3(+)CD4(+) was increased (p < 0.001). Patients with mechanical prosthesis had increased absolute and relative number of CD45RA(+)CD62L(\u2212)CD3(+)CD8(+) cells (p = 0.006). Also the relative number of CD3(+)CD4(+) cells was reduced (p = 0.04). We assume that altered composition of T cell subsets points at development of xenograft rejection reaction against both mechanical and biological heart valve prostheses.",
   "publish_time": "2016 Feb 17",
   "authors": [
      "['Barbarash, L.', 'Kudryavtsev, I.', 'Rutkovskaya, N.', 'Golovkin, A.']"
   ],
   "journal": "Mediators Inflamm",
   "has_full_text": "True",
   "id": "5ef330551dd1c93b532c49305501f9a5abd3d799",
   "fhir_link": "Commercial/5ef330551dd1c93b532c49305501f9a5abd3d799"
}