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<http://fhircat.org/cord-19/metadata/979b57435d23b8a685e05afe29b41c6f7aa73336> dc:abstract "The first imported case of Middle East respiratory syndrome (MERS) in China recently occurred, allowing for the characterization of antibody titers in a series of the patient's sera using the following methods based on recombinant viral structural antigens: inactivated MERS coronavirus (MERS-CoV) enzyme-linked immunosorbent assay (ELISA), recombinant MERS-CoV spike (S, or fragments of S) ELISA, nucleoprotein (NP) ELISA and MERS S pseudovirus particle-based neutralization test (ppNT). A longitudinal profile of the infection showed that seroconversion detected by ELISAs based on the recombinant extracellular domain, S, S1 and receptor-binding domain (RBD) antigens occurred as early as neutralizing antibodies were detected by the ppNT and earlier than antibodies were detected by the inactivated MERS-CoV and N-terminal domain (NTD) ELISAs. Antibodies detected by the NP ELISA occurred last. Strong correlations were found between the S1, RBD and NP ELISAs and the inactivated MERS-CoV ELISA. The S and RBD ELISAs were highly correlated with the commercial S1 ELISA. The S ELISA strongly correlated with the ppNT, although the MERS-CoV, S1, NTD and RBD ELISAs were also significantly correlated with the ppNT (P<0.001)." ;
    dc:creator "['Wang, Wenling', 'Wang, Huijuan', 'Deng, Yao', 'Song, Tie', 'Lan, Jiaming', 'Wu, Guizhen', 'Ke, Changwen', 'Tan, Wenjie']" ;
    dc:identifier <http://dx.doi.org/10.1038/emi.2016.114>,
        <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148018>,
        <https://www.ncbi.nlm.nih.gov/pubmed/27826140> ;
    dc:issued "2016-01-01"^^xsd:date ;
    dc:license "CC BY" ;
    dc:title "Characterization of anti-MERS-CoV antibodies against various recombinant structural antigens of MERS-CoV in an imported case in China" ;
    sso:has_full_text "False" ;
    sso:journal "Emerg Microbes Infect" ;
    sso:sha "979b57435d23b8a685e05afe29b41c6f7aa73336" ;
    sso:source_x "PMC" .