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<http://fhircat.org/cord-19/metadata/b35188139844b656464c0727fa39ec03d970c443> fhir_link: <https://fhircat.org/cord-19/fhir/Commercial/b35188139844b656464c0727fa39ec03d970c443> ;
    dc:abstract "The mechanisms involved in the chronic hepatitis C progression are incompletely understood. The aim was to analyze the association between 2′5′oligoadenylate synthetase 1,2 and 3 (OAS1-3) and myxovirus resistance proteins 1 (Mx1) polymorphisms and severity of liver disease in human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients. We performed a cross-sectional study in 219 patients that underwent a liver biopsy. DNA genotyping for Mx1 (rs469390), OAS1 (rs2285934), OAS2 (rs1293762) and OAS3 (rs2010604) was performed by using GoldenGate assay. The outcome variables ion liver biopsy were: (i) significant fibrosis (F ≥ 2); (ii) moderate activity grade (A ≥ 2). Additive model of inheritance for genetic association test was used. The likelihood of having significant fibrosis (F ≥ 2) was lower in patients carrying OAS2 rs1293762 A allele [adjusted odds ratio (aOR) = 0.51; p = 0.040]. Besides, the likelihood of having moderate activity grade (A ≥ 2) was higher in patients carrying Mx1 rs464397 C allele (aOR = 1.63; p = 0.028) and Mx1 rs469390 G allele (aOR = 1.97; p = 0.005), while it was lower in patients carrying OAS1 rs2285934 A allele (aOR = 0.64; p = 0.039) and OAS2 rs1293762 A allele (aOR = 0.41; p = 0.009). In conclusion, Mx1 and OAS1-2 polymorphisms were associated with the severity of liver disease in HIV/HCV-coinfected patients, suggesting a significant role in the progression of hepatic fibrosis." ;
    dc:creator "['García-Álvarez, Mónica', 'Berenguer, Juan', 'Jiménez-Sousa, María A.', 'Pineda-Tenor, Daniel', 'Aldámiz-Echevarria, Teresa', 'Tejerina, Francisco', 'Diez, Cristina', 'Vázquez-Morón, Sonia', 'Resino, Salvador']" ;
    dc:identifier <http://dx.doi.org/10.1038/srep41516>,
        <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282518>,
        <https://www.ncbi.nlm.nih.gov/pubmed/28139728> ;
    dc:issued "2017-01-01"^^xsd:date ;
    dc:license "CC BY" ;
    dc:title "Mx1, OAS1 and OAS2 polymorphisms are associated with the severity of liver disease in HIV/HCV-coinfected patients: A cross-sectional study" ;
    sso:has_full_text "True" ;
    sso:journal "Sci Rep" ;
    sso:sha "b35188139844b656464c0727fa39ec03d970c443" ;
    sso:source_x "PMC" .