{
   "sha": "d3622e7ade6a1af92f1f239619932a3863c77e19",
   "source_x": "PMC",
   "title": "IL-10: A Multifunctional Cytokine in Viral Infections",
   "doi": "http://dx.doi.org/10.1155/2017/6104054",
   "pmcid": "PMC5337865",
   "pubmed_id": "28316998",
   "license": "CC BY",
   "abstract": "The anti-inflammatory master regulator IL-10 is critical to protect the host from tissue damage during acute phases of immune responses. This regulatory mechanism, central to T cell homeostasis, can be hijacked by viruses to evade immunity. IL-10 can be produced by virtually all immune cells, and it can also modulate the function of these cells. Understanding the effects of this multifunctional cytokine is therefore a complex task. In the present review we discuss the factors driving IL-10 production and the cellular sources of the cytokine during antiviral immune responses. We particularly focus on the IL-10 regulatory mechanisms that impact antiviral immune responses and how viruses can use this central regulatory pathway to evade immunity and establish chronic/latent infections.",
   "publish_time": "2017 Feb 20",
   "authors": [
      "['Rojas, Jos\u00e9 M.', 'Avia, Miguel', 'Mart\u00edn, Ver\u00f3nica', 'Sevilla, Noem\u00ed']"
   ],
   "journal": "J Immunol Res",
   "has_full_text": "True",
   "id": "d3622e7ade6a1af92f1f239619932a3863c77e19",
   "fhir_link": "Commercial/d3622e7ade6a1af92f1f239619932a3863c77e19"
}