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<http://fhircat.org/cord-19/metadata/c5139e673b41fa64eb80936bc9d63e83bf3c7172> fhir_link: <https://fhircat.org/cord-19/fhir/Commercial/c5139e673b41fa64eb80936bc9d63e83bf3c7172> ;
    dc:abstract "Broadly Cross clade Neutralizing (BCN) antibodies are recognized as potential therapeutic tools and leads for the design of a vaccine that can protect human beings against various clades of Human Immunodeficiency Virus (HIV). In the present study, we screened plasma of 88 HIV-1 infected ART naïve individuals for their neutralization potential using a standard panel of 18 pseudoviruses belonging to different subtypes and different levels of neutralization. We identified 12 samples with good breadth of neutralization (neutralized >90% of the viruses). Four of these samples neutralized even the difficult-to-neutralize tier-3 pseudoviruses with great potency (GMT > 600). Analysis of neutralization specificities indicated that four samples had antibodies with multiple epitope binding specificities, viz. CD4-binding site (CD4BS), glycans in the V1/V2 and V3 regions and membrane proximal external region (MPER). Our findings indicate the strong possibility of identifying highly potent bNAbs with known or novel specificities from HIV-1 subtype C infected individuals from India that can be exploited as therapeutic tools or lead molecules for the identification of potential epitopes for design of a protective HIV-1 vaccine." ;
    dc:creator "['Cheedarla, Narayanaiah', 'Precilla, K. Lucia', 'Babu, Hemalatha', 'Vijayan, K. K. Vidya', 'Ashokkumar, Manickam', 'Chandrasekaran, Padmapriyadarsini', 'Kailasam, Nandagopal', 'Sundaramurthi, Jagadish Chandrabose', 'Swaminathan, Soumya', 'Buddolla, Viswanath', 'Vaniambadi, S. Kalyanaraman', 'Ramanathan, V. D.', 'Hanna, Luke Elizabeth']" ;
    dc:identifier <http://dx.doi.org/10.1038/srep46557>,
        <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5402285>,
        <https://www.ncbi.nlm.nih.gov/pubmed/28436427> ;
    dc:issued "2017-01-01"^^xsd:date ;
    dc:license "CC BY" ;
    dc:title "Broad and potent cross clade neutralizing antibodies with multiple specificities in the plasma of HIV-1 subtype C infected individuals" ;
    sso:has_full_text "True" ;
    sso:journal "Sci Rep" ;
    sso:sha "c5139e673b41fa64eb80936bc9d63e83bf3c7172" ;
    sso:source_x "PMC" .