{
   "sha": "52d4bf773931d4aaef87f60b1b060e93aa456fba",
   "source_x": "PMC",
   "title": "Memory CD8 T cells mediate severe immunopathology following respiratory syncytial virus infection",
   "doi": "http://dx.doi.org/10.1371/journal.ppat.1006810",
   "pmcid": "PMC5766251",
   "pubmed_id": "29293660",
   "license": "CC BY",
   "abstract": "Memory CD8 T cells can provide protection from re-infection by respiratory viruses such as influenza and SARS. However, the relative contribution of memory CD8 T cells in providing protection against respiratory syncytial virus (RSV) infection is currently unclear. To address this knowledge gap, we utilized a prime-boost immunization approach to induce robust memory CD8 T cell responses in the absence of RSV-specific CD4 T cells and antibodies. Unexpectedly, RSV infection of mice with pre-existing CD8 T cell memory led to exacerbated weight loss, pulmonary disease, and lethal immunopathology. The exacerbated disease in immunized mice was not epitope-dependent and occurred despite a significant reduction in RSV viral titers. In addition, the lethal immunopathology was unique to the context of an RSV infection as mice were protected from a normally lethal challenge with a recombinant influenza virus expressing an RSV epitope. Memory CD8 T cells rapidly produced IFN-\u03b3 following RSV infection resulting in elevated protein levels in the lung and periphery. Neutralization of IFN-\u03b3 in the respiratory tract reduced morbidity and prevented mortality. These results demonstrate that in contrast to other respiratory viruses, RSV-specific memory CD8 T cells can induce lethal immunopathology despite mediating enhanced viral clearance.",
   "publish_time": "2018 Jan 2",
   "authors": [
      "['Schmidt, Megan E.', 'Knudson, Cory J.', 'Hartwig, Stacey M.', 'Pewe, Lecia L.', 'Meyerholz, David K.', 'Langlois, Ryan A.', 'Harty, John T.', 'Varga, Steven M.']"
   ],
   "journal": "PLoS Pathog",
   "has_full_text": "False",
   "id": "52d4bf773931d4aaef87f60b1b060e93aa456fba"
}