{
   "sha": "5669349639eae4f58b4fecca26fcc271094c70ba",
   "source_x": "PMC",
   "title": "Detection and Characterization of Homologues of Human Hepatitis Viruses and Pegiviruses in Rodents and Bats in Vietnam",
   "doi": "http://dx.doi.org/10.3390/v10030102",
   "pmcid": "PMC5869495",
   "pubmed_id": "29495551",
   "license": "CC BY",
   "abstract": "Rodents and bats are now widely recognised as important sources of zoonotic virus infections in other mammals, including humans. Numerous surveys have expanded our knowledge of diverse viruses in a range of rodent and bat species, including their origins, evolution, and range of hosts. In this study of pegivirus and human hepatitis-related viruses, liver and serum samples from Vietnamese rodents and bats were examined by PCR and sequencing. Nucleic acids homologous to human hepatitis B, C, E viruses were detected in liver samples of 2 (1.3%) of 157 bats, 38 (8.1%), and 14 (3%) of 470 rodents, respectively. Hepacivirus-like viruses were frequently detected (42.7%) in the bamboo rat, Rhizomys pruinosus, while pegivirus RNA was only evident in 2 (0.3%) of 638 rodent serum samples. Complete or near-complete genome sequences of HBV, HEV and pegivirus homologues closely resembled those previously reported from rodents and bats. However, complete coding region sequences of the rodent hepacivirus-like viruses substantially diverged from all of the currently classified variants and potentially represent a new species in the Hepacivirus genus. Of the viruses identified, their routes of transmission and potential to establish zoonoses remain to be determined.",
   "publish_time": "2018 Feb 28",
   "authors": [
      "['Van Nguyen, Dung', 'Van Nguyen, Cuong', 'Bonsall, David', 'Ngo, Tue Tri', 'Carrique-Mas, Juan', 'Pham, Anh Hong', 'Bryant, Juliet E.', 'Thwaites, Guy', 'Baker, Stephen', 'Woolhouse, Mark', 'Simmonds, Peter']"
   ],
   "journal": "Viruses",
   "has_full_text": "True",
   "id": "5669349639eae4f58b4fecca26fcc271094c70ba",
   "fhir_link": "Commercial/5669349639eae4f58b4fecca26fcc271094c70ba"
}