@prefix : <http://semanticscholar.org/cv-research/> .
@prefix dc: <http://purl.org/dc/terms/> .
@prefix fhir_link: <http://hl7.org/fhir/link/> .
@prefix ncit: <http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix sso: <http://semanticscholar.org/cv-research/> .
@prefix whocv: <http://semanticscholar.org/cv-research/WHO#> .
@prefix xml: <http://www.w3.org/XML/1998/namespace> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<http://fhircat.org/cord-19/metadata/c0b11b19a87de55ec7803cad2e855942ce498d6b> fhir_link: <https://fhircat.org/cord-19/fhir/Commercial/c0b11b19a87de55ec7803cad2e855942ce498d6b> ;
    dc:abstract "Porcine epidemic diarrhea (PED) is a highly contagious disease in newborn piglets. In our previous study, a genetically engineered Lactobacillus casei oral vaccine (pPG-COE-DCpep/L393) expressing a dendritic cell (DC)-targeting peptide fused with porcine epidemic diarrhea virus (PEDV) COE antigen was developed. This vaccine induced significant levels of anti-PEDV specific IgG and IgA antibody responses in mice, indicating a potential strategy against PEDV infection. In this study, pPG-COE-DCpep/L393 was used for oral vaccination of newborn piglets against PEDV. We then assessed the immune responses and protection efficacy of pPG-COE-DCpep/L393. An indirect enzyme-linked immunosorbent assay (ELISA) showed that the recombinant Lactobacillus vaccine elicits a specific systemic and mucosal immune response. The T-helper cells mediated by pPG-COE-DCpep/L393 and PEDV infection display a Th1 phenotype. The histopathological results showed that pPG-COE-DCpep/L393 promotes lymphocyte proliferation and effectively protects piglets against PEDV infection. The transforming growth factor-β level indicated that the recombinant Lactobacillus vaccine plays a role in anti-inflammatory responses in mesenteric lymph nodes during PEDV infection. These results show that pPG-COE-DCpep/L393 is a potential vaccine against PEDV infection." ;
    dc:creator "['Hou, Xingyu', 'Jiang, Xinpeng', 'Jiang, Yanping', 'Tang, Lijie', 'Xu, Yigang', 'Qiao, Xinyuan', 'Liu, Min', 'Cui, Wen', 'Ma, Guangpeng', 'Li, Yijing']" ;
    dc:identifier <http://dx.doi.org/10.3390/v10030106>,
        <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869499>,
        <https://www.ncbi.nlm.nih.gov/pubmed/29494530> ;
    dc:issued "2018-01-01"^^xsd:date ;
    dc:license "CC BY" ;
    dc:title "Oral Immunization against PEDV with Recombinant Lactobacillus casei Expressing Dendritic Cell-Targeting Peptide Fusing COE Protein of PEDV in Piglets" ;
    sso:has_full_text "True" ;
    sso:journal "Viruses" ;
    sso:sha "c0b11b19a87de55ec7803cad2e855942ce498d6b" ;
    sso:source_x "PMC" .